There are mainly three types of Insulin Preparations. Lets see about the onset, peak and duration of each of those. Clinical insulin contains mixtures of insulin plus other substances including preservatives.
Types of Insulin Preparations
Variations of Human Insulin molecule is called insulin analogues. They are called as analogues because tehy are not technically insulin, but have the human insulin hormones glucose management functionality. Insulin preparations are classified based on the time of action of Insulin after administration.
1. RAPID ACTING INSULIN
They are Insulin lispro, Insulin Aspart, Insulin glusine etc
Onset of acting is within 10 – 20 minutes of administration
Peak is within 0.5 to 1.5 hours.
Duration is around 3 – 5 hours.
2. SHORT ACTING INSULIN
Eg. Regular Insulin
Onset of action is within 30 – 60 minutes.
Peak is within 1-5 hours.
Duration is around 6 – 10 hours.
3. INTERMEDIATE ACTING INSULIN
Eg. NPH Insulin
Onset of action is 1- 2 hours.
Peak of action is within 6 – 14 hours.
Duration of action is around 16 – 24 hours.
4. LONG ACTING INSULIN
Eg. Insulin Glargine, Insulin Detemir
Onset of Action is within 1-2 hours
Peak is within 12 – 24 hours
Duration is above 18 hours.
5. COMBINATION INSULIN PRODUCTS
The combination products begin to work with the shorter acting insulin (5–15 minutes for fast-acting, and 30 minutes for short acting), and remain active for 16 to 24 hours. There are several variations with different proportions of the mixed insulins (e.g. Novolog Mix 70/30 contains 70% aspart protamine [akin to NPH], and 30% aspart.)
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